Mitochondria, the organelles inside each cell that generate energy, play a crucial role in a tumor’s ability to generate the energy needed to invade healthy tissue. Mitochondria exhibit a remarkable ability to change theirshape and spatial distribution within a cell, said Raquel Sitcheran, PhD, assistant professor at the Texas College of Medicine and corresponding author of the study. We uncovered a surprising new regulator of mitochondrial dynamics that is important for promoting cancer cell invasion. This regulator, which is called NIK, is a protein that regulates immune cell function and inflammation. Their new finding is that NIK is also present on mitochondria in brain, pancreatic and breast cancer cells. When the research team removed all NIK expression using CRISPR -Cas9 genome editing, the cancer cells were no longer able to invade. On the other hand, NIK is upregulated when a cell becomes cancerous, and the more invasive tumors had higher activation of the NIK pathway. In cancer cells, mitochondria typically undergo fission and are small in size, allowing them to move rapidly to areas of the cell with high energy demandsusually the branches of a cell that are invading surrounding tissue. Without NIK, the mitochondria become fused and are impaired in their ability to move efficiently to areas of the cell that initiate and drive the process of invasion. Theres a link between NIK, mitochondrial function and cancer cell invasion, Sitcheran said. additional infoIt gives us a new angle in thinking about the role of mitochondria in cancer progression. -more- Page 2 TEXAS A&M RESEARCHERS DISCOVER A NEW REGULATOR OF MITOCHONDRIA IN INVASIVE CANCER GROWTH To understand how this works, think of the mitochondriaunder normal circumstances, when they have plenty of NIKas being able to morph into different shapes, from a slow, hulking bus to a nimble race car. Mitochondria are very dynamic and can split, fuse and move in the cell, Sitcheran said.
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Score touchdowns. However, if States offense repeats the pattern of previous close losses-if it just moves the ball between the 20s, settles for field goals in the red zone, or commits drive stopping penalties-or turnovers-this game is over. UNC has perhaps the most explosive passing game NC State has seen all season. Mitch Trubisky throws to four talented wide outs. Plus, the Tar Heels tight ends and running backs can and do catch the football. Its not unusual to see Trubisky spread the ball among nine or 10 different receivers in a single game, and he does so with almost 70 percent accuracy. Trubisky has thrown just four interceptions in 370 passes, best in the ACC. The Tar Heels fast tempo and running game, along with the Trubisky air show, make this an offense that can score points in a hurry. More InfoIf the Wolfpack wants to play a 13th game, it will have to make its 12th game the best game of the year come Friday at High Noon. Tar Heels and Orlando For North Carolina, the stakes are also high. Although Virginia Tech wins the Coastal Division and the ensuing matchup with Clemson in the ACC Championship Game if it beats Virginia as expected, the Tar Heels must put their best foot forward Friday and hope.
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